We’ve read of one very limited study (3 people) in London where Botox was applied to the toes, here’s our post: https://www.raynauds.org/2018/09/23/botox-applied-to-the-toes-restores-heat-to-feet/. To date, it’s the only one we’ve seen testing this approach to the feet.
While Botox for Raynaud’s symptoms appears to have promise, the numbers so far are very small and results are still not yet endorsed by the medical community. However, calcium channel blockers have been clinically proven to help with Raynaud’s symptoms for years and are generally the first line of defense doctors prescribe for Raynaud’s patients.
I personally haven’t tried Botox, but can say that the CCB drugs, along with being more careful with lifestyle issues, have helped me over the years avoid digital ulcers on my toes. Hope this input helps!